p 53 suppresses mutagenic RAD 52 and POL pathways by orchestrating DNA 1 replication restart homeostasis
نویسندگان
چکیده
منابع مشابه
p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways
Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet, replication-mediated genomic instability is integral to oncogenesis, and p53 mutations promote tumor progression and drug-resistance. By delineating human and murine separation-of-function p53 alleles, we find that p53 null and gain-of-function (GOF) mutations exhibit defects in restart of stalled or...
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